Protease-Antiprotease Interactions and the Rationale for Therapeutic Protease Inhibitors

摘要: A number of pancreatic enzymes have been suggested as the initiating factor for acute pancreatitis. In particular, relationship between proteases and antiproteases has examined extensively, based on suspicion that an imbalance them is central in pathogenesis Animal studies with antiproteolytic agents models pancreatitis shown improvement outcome. However, more recently, prospective, randomized, multicentre trials treating human drugs (aprotinin, gabexate mesilate, even fresh frozen plasma) failed to show any benefit clinical setting. Thus, clinically, it seems likely therapy no effect course severe Today, mortality determined by septic complications due infected necroses late phase 2–3 weeks after onset disease. Death early disea...