Transcriptional Regulation of the Pou Gene Oct-6 in Schwann Cells
作者： Wim Mandemakers , Ronald Zwart , Robert Kraay , Gerard Grosveld , Anneke Graus Martine Jaegle
DOI: 10.1007/978-1-4615-4685-6_2
关键词: Transfection 、 Regulatory sequence 、 Schwann cell 、 Biology 、 Transcriptional regulation 、 Cell biology 、 POU domain 、 Regulation of gene expression 、 Transcription factor 、 Schwann cell differentiation
摘要: Genetic evidence suggests that the POU transcription factor Oct-6 plays a pivotal role as an intracellular regulator of Schwann cell differentiation. In absence function cells are generated in appropriate numbers and these differentiate normally up to promyelin stage at which they transiently arrest. During peripheral nerve development expression is initiated precursors strongly upregulated cells. subsequently extinguished terminally differentiating Thus, identification characterisation DNA elements involved this specific regulation may lead us signaling cascade axon-derived signals drive differentiation initiate myelination. Here we present experiments aim identifying such regulatory sequences.
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