Hsp70 release from peripheral blood mononuclear cells.

作者: Claire Hunter-Lavin , Emma L. Davies , Maria M.F.V.G. Bacelar , Michael J. Marshall , Sarah M. Andrew

DOI: 10.1016/J.BBRC.2004.09.075

关键词: SecretionLipid raftWhole bloodLactate dehydrogenasePeripheral blood mononuclear cellCell damageHsp70MonensinMolecular biologyBiology

摘要: … of Hsp70 into blood and culture medium from peripheral blood mononuclear cells (PBMCs), … Western blot showing the presence of Hsp70 in peripheral blood mononuclear cell (PBMC) …

参考文章(43)
Sajeda Meghji, Peter Tabona, Monika Preuss, Sean P. Nair, Stephen Poole, Brian Henderson, Andrew D. Miller, Michael Wilson, Sahar Khan, St. John V. Crean, Sandy Carne, Krisanavane Reddi, Homogeneous Escherichia coli chaperonin 60 induces IL-1 beta and IL-6 gene expression in human monocytes by a mechanism independent of protein conformation. Journal of Immunology. ,vol. 161, pp. 1414- 1421 ,(1998)
Alexzander Asea, Stine-Kathrein Kraeft, Evelyn A. Kurt-Jones, Mary Ann Stevenson, Lan Bo Chen, Robert W. Finberg, Gloria C. Koo, Stuart K. Calderwood, HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nature Medicine. ,vol. 6, pp. 435- 442 ,(2000) , 10.1038/74697
Willem van Eden, Ad Koets, Peter van Kooten, Berent Prakken, Ruurd van der Zee, Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity. Vaccine. ,vol. 21, pp. 897- 901 ,(2003) , 10.1016/S0264-410X(02)00538-8
Christiane Habich, Karina Baumgart, Hubert Kolb, Volker Burkart, The receptor for heat shock protein 60 on macrophages is saturable, specific, and distinct from receptors for other heat shock proteins. Journal of Immunology. ,vol. 168, pp. 569- 576 ,(2002) , 10.4049/JIMMUNOL.168.2.569
Robert Gastpar, Catharina Gross, Lydia Rossbacher, Joachim Ellwart, Julia Riegger, Gabriele Multhoff, The Cell Surface-Localized Heat Shock Protein 70 Epitope TKD Induces Migration and Cytolytic Activity Selectively in Human NK Cells Journal of Immunology. ,vol. 172, pp. 972- 980 ,(2004) , 10.4049/JIMMUNOL.172.2.972
Amir Kol, Andrew H. Lichtman, Robert W. Finberg, Peter Libby, Evelyn A. Kurt-Jones, Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells Journal of Immunology. ,vol. 164, pp. 13- 17 ,(2000) , 10.4049/JIMMUNOL.164.1.13
C Retzlaff, Y Yamamoto, P S Hoffman, H Friedman, T W Klein, Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures. Infection and Immunity. ,vol. 62, pp. 5689- 5693 ,(1994) , 10.1128/IAI.62.12.5689-5693.1994
David J. Lamb, Wafaa El-Sankary, Gordon A.A. Ferns, Molecular mimicry in atherosclerosis: a role for heat shock proteins in immunisation. Atherosclerosis. ,vol. 167, pp. 177- 185 ,(2003) , 10.1016/S0021-9150(02)00301-5