Protecting group for synthesizing oligonucleotide analogs
作者： Zacharia S. Cheruvallath , Vasulinga T. Ravikumar , Douglas L. Cole , Daniel C. Capaldi
DOI:
关键词: Nucleoside 、 Oligonucleotide 、 Chemistry 、 Phosphoramidite 、 Analog synthesis 、 Protecting group 、 Combinatorial chemistry
摘要: A 2-N-amidoethyl protected nucleoside analog phosphoramidite of formula (1): ##STR1## is useful in the synthesis a wide variety oligonucleotide analogs. Coupling yields with (1) solution or solid phase are high and protecting group can be removed easily under standard conditions.
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