Biological properties of Norwalk agent of acute infectious nonbacterial gastroenteritis.

摘要: SummaryAcute infectious nonbacterial gastroenteritis was induced in adult volunteers through three serial passages by oral administration of bacteria-free stool filtrates. This suggested that a replicating agent subbacterial size responsible for the observed disease. The biophysical properties agent, as assayed volunteers, were consistent with those small virus, most closely related to parvovirus group among known animal viruses. appeared have diameter less than 66 nm and likely 36 nm. It lack lipid containing envelope acid stable. stable heating at 60° 30 min. be relatively host specific man conferred least short-term immunity. Because high frequency disease unselected widespread natural immunity this may absent or perhaps incomplete. Preliminary evidence Norwalk replicated an vitro system, human fetal intestina...