Molecularly characterised xenograft tumour mouse models: valuable tools for evaluation of new therapeutic strategies for secondary liver cancers.

摘要: To develop and evaluate new therapeutic strategies for the treatment of human cancers, well-characterised preclinical model systems are a prerequisite. this aim, we have established xenotransplantation mouse models corresponding cell cultures from surgically obtained secondary liver tumours. Established xenograft tumours were patho- immunohistologically characterised, expression levels cancer-relevant genes quantified in paired original derivative applying RT-PCR-based array technology. Most characteristic morphological immunohistochemical features shown to be maintained. No differences found concerning involved cycle regulation oncogenesis. Interestingly, cytokine matrix metalloproteinase encoding appeared expressed differentially. Thus, closely reflecting pathohistological molecular characteristics selected may therefore provide useful tools analyses antitumour vivo.