Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue.
作者： David J Monsma , Noel R Monks , David M Cherba , Dawna Dylewski , Emily Eugster
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摘要: Background There is resurgence within drug and biomarker development communities for the use of primary tumorgraft models as improved predictors patient tumor response to novel therapeutic strategies. Despite perceived advantages over cell line derived xenograft models, there limited data comparing genotype phenotype tumorgrafts donor tumor, limiting determination molecular relevance model. This report directly compares genomic characteristics tumors including gene expression, oncogenic mutation status.
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