Identification of acetylcholine receptors in adult rat trigeminal ganglion neurons.
作者： L. Liu , W. Pugh , H. Ma , S.A. Simon
DOI: 10.1016/0006-8993(93)90609-Q
关键词: Biology 、 Patch clamp 、 Trigeminal ganglion 、 Hexamethonium 、 Acetylcholine receptor 、 Mecamylamine 、 Molecular biology 、 Nicotinic agonist 、 Dimethylphenylpiperazinium 、 Neuroscience 、 Acetylcholine
摘要: Nicotinic acetylcholine receptors (nAChRs) were identified in a subpopulation of cultured adult rat trigeminal ganglia (TG) neurons by whole-cell patch-clamp recordings. Dimethylphenylpiperazinium (DMPP), nAChR agonist, induced inward currents 21/68 TG having soma diameters greater than 28 microns. These inhibited hexamethonium, mecamylamine and atropine, indicating the presence neuronal ganglionic-type nAChRs. This interpretation is consistent with finding that nicotine- or DMPP-induced not alpha-bungarotoxin (alpha-Bng) 5 9 cells tested this compound. However, 2 tested, completely alpha-Bng, remaining two partially alpha-Bng. About 22% > = microns specifically labeled FITC-labeled whereas only 2% < labeled. data taken together suggest more one subtype present TG.
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