A rapid capsaicin-activated current in rat trigeminal ganglion neurons.

摘要: A subpopulation of pain fibers are activated by capsaicin, the ingredient in red peppers that produces a burning sensation when eaten or placed on skin. Previous studies dorsal root ganglion neurons indicated capsaicin activates sensory nerves via single slowly activating and inactivating inward current. In rat trigeminal neurons, we identified second capsaicin-activated This current can be distinguished from slow one it rapidly inactivates, requires Ca2+ for activation, is insensitive to potent agonist resiniferatoxin. The rapid current, like slower one, inhibited ruthenium capsazepine. two currents share many similarities with lowering pH 6.0. These include kinetics, reversal potentials, responses Ca2+, inhibition results suggest acidic stimuli may an endogenous activator capsaicin-gated therefore rationalize why produced plasma acidity increased, as occurs during ischemia inflammation.