Transdiagnostic expression of interoceptive abnormalities in psychiatric conditions

摘要: ABSTRACT Background Interoception, the sensing of information about internal physiological state body, is proposed to be fundamental normal and abnormal affective feelings. We undertook a cross-sectional characterisation cardiac interoception in patients accessing secondary mental health services understand how interoceptive abnormalities relate psychiatric symptoms diagnoses. Methods Patients attending adult (205 female, 101 male) controls (42 21 participated. Clinical diagnoses spanned disorders, personality disorders psychoses. Physiological, bio-behavioural subjective measures included: 1) Basal heart rate variability (HRV); 2) afferent effects on emotional processing (cardiac cycle modulation ratings fear vs. neutral faces); 3) perceptual accuracy, confidence, metacognitive insight heartbeat detection, and; 4) self-reported sensitivity bodily sensations. tested for transdiagnostic differences between controls, then correlations symptoms, group across clinical diagnostic categories. Results differed from HRV, processing, discrimination detection confidence. Anxiety depression symptom severity correlated particularly with experiences. Significant categories were observed interoception. schizophrenia relative other intriguingly showed opposite emotion processing. Conclusions This multilevel identified associated Interoceptive mechanisms have potential value stratification therapeutic targeting disorders.