Antibodies Against Glutathione S-Transferase T1 (GSTT1) in Patients With GSTT1 Null Genotype as Prognostic Marker: Long-Term Follow-Up After Liver Transplantation
作者： Margarita Rodriguez-Mahou , Magdalena Salcedo , Eduardo Fernandez-Cruz , Jose Luis R. Tiscar , Rafael Ba??ares
DOI: 10.1097/01.TP.0000259963.47350.DA
关键词: Confidence interval 、 Glutathione-S-Transferase T1 、 Liver transplantation 、 Transplantation 、 Gastroenterology 、 Autoantibody 、 Internal medicine 、 Genotype 、 Immunology 、 Antibody 、 Long term follow up 、 Medicine
摘要: An objective to improve the evolution of transplants is identify risk biomarkers morbidity and loss allograft. In liver transplant (LTX) recipients, an association has been demonstrated between presence mismatch for glutathione S-transferase T1 (GSTT1) development de novo immune hepatitis (IH). 419 LTX patients we analyzed, a period 1 14 years, "atypical" autoantibodies directed against GSTT1 their relationship with genotype developing IH. A total 6.9% recipients had 24 showed (recipient/donor) genotype. From this last group, up 70% developed IH graft dysfunction after (95% confidence interval: 17.4-37.5 months). null genotype, evaluation useful monitoring
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sci-hub.se 参考文章(26)
Raimund Sprenger, Robert Schlagenhaufer, Reinhold Kerb, Claudia Bruhn, Jurgen Brockmoller, Ivar Roots, Ulrich Brinkmann, Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation. Pharmacogenetics. ,vol. 10, pp. 557- 565 ,(2000) , 10.1097/00008571-200008000-00009
S Pemble, K R Schroeder, S R Spencer, D J Meyer, E Hallier, H M Bolt, B Ketterer, J B Taylor, Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochemical Journal. ,vol. 300, pp. 271- 276 ,(1994) , 10.1042/BJ3000271
Jonathan D. ROWE, Edward NIEVES, Irving LISTOWSKY, Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera Biochemical Journal. ,vol. 325, pp. 481- 486 ,(1997) , 10.1042/BJ3250481
Isabel Aguilera, Ingeborg Wichmann, Miguel Angel Gentil, Francisca Gonzalez-Escribano, Antonio Nuñez-Roldan, Alloimmune response against donor glutathione S-transferase T1 antigen in renal transplant recipients. American Journal of Kidney Diseases. ,vol. 46, pp. 345- 350 ,(2005) , 10.1053/J.AJKD.2005.04.022
M. Kempkes, F. A. Wiebel, K. Golka, P. Heitmann, H. M. Bolt, Comparative genotyping and phenotyping of glutathione S-transferase GSTT1 Archives of Toxicology. ,vol. 70, pp. 306- 309 ,(1996) , 10.1007/S002040050278
Charles Mullighan, Sue Heatley, Kathleen Doherty, Ferenc Szabo, Andrew Grigg, Timothy Hughes, Anthony Schwarer, Jeff Szer, Brian Tait, Bik To, Peter Bardy, Non-HLA immunogenetic polymorphisms and the risk of complications after allogeneic hemopoietic stem-cell transplantation. Transplantation. ,vol. 77, pp. 587- 596 ,(2004) , 10.1097/01.TP.0000111769.45088.A2
Helen Fernandes, Baburao Koneru, Neil Fernandes, Meera Hameed, Marion C. Cohen, Elizabeth Raveche, Stanley Cohen, Investigation of promoter polymorphisms in the tumor necrosis factor-alpha and interleukin-10 genes in liver transplant patients. Transplantation. ,vol. 73, pp. 1886- 1891 ,(2002) , 10.1097/00007890-200206270-00006
Aya Miyagawa-Hayashino, Hironori Haga, Takaki Sakurai, Tomoyuki Shirase, Toshiaki Manabe, Hiroto Egawa, De novo autoimmune hepatitis affecting allograft but not the native liver in auxiliary partial orthotopic liver transplantation. Transplantation. ,vol. 76, pp. 271- 272 ,(2003) , 10.1097/01.TP.0000072338.88465.59
Isabel Aguilera, Jose M. Sousa, Francisco Gavilán, Angel Bernardos, Ingeborg Wichmann, Antonio Nuñez-Roldán, Glutathione S-transferase T1 mismatch constitutes a risk factor for de novo immune hepatitis after liver transplantation Liver Transplantation. ,vol. 10, pp. 1166- 1172 ,(2004) , 10.1002/LT.20209
James Neuberger, Transplantation for autoimmune hepatitis. Seminars in Liver Disease. ,vol. 22, pp. 379- 386 ,(2002) , 10.1055/S-2002-35707