Antihyperglycemic, Antihyperlipidemic and Antiglycation Effects of Byrsonima crassifolia Fruit and Seed in Normal and Streptozotocin-Induced Diabetic Rats
作者： Rosa Martha Perez-Gutierrez , Alethia Muñiz-Ramirez , Yolanda Gomez Gomez , Esther Bautista Ramírez
DOI: 10.1007/S11130-010-0181-5
关键词: Thiobarbituric acid 、 Glutathione 、 Endocrinology 、 Internal medicine 、 Hyperlipidemia 、 Superoxide dismutase 、 Streptozotocin 、 Byrsonima crassifolia 、 Chemistry 、 Lipid peroxidation 、 Glycogen
摘要: The hypoglycemic effects of hexane, chloroform and methanol extracts from fruits seeds Byrsonima crassifolia were evaluated by oral administration to normoglycemic streptozotocin-induced severe diabetic rats (SD). anti-diabetic effect was examined blood glucose, triglycerides, lipid peroxidation, total cholesterol levels in the serum, glycogen content liver skeletal muscles, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) oxidized (GSSG) levels. most active obtained with hexane. Hexane increased SOD, GSH, GSSG CAT, hepatic content, glucose-6-phosphatase (G6Pase) plasma insulin They also decreased glucokinase (GK) TBAR (thiobarbituric acid assay). In conclusion, possesses significant antihyperglycemic properties after 4 h a single dose. It can improve hyperlipidemia hyperinsulinemia rats. Both exhibited inhibitory activity against AGEs (advanced glycation end products) formation IC50 values ranging 94.3 138.7 μg/ml. Therefore, B. be considered as potential safe agent.
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