Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies.
作者： Simonetta M. Leto , Livio Trusolino
DOI: 10.1007/S00109-014-1161-2
关键词: Oncology 、 Human genetics 、 Cetuximab 、 Molecular medicine 、 Internal medicine 、 Targeted therapy 、 Colorectal cancer 、 Drug resistance 、 Growth factor receptor 、 Immunology 、 Medicine 、 Panitumumab
摘要: … Aberrant activation of MET may occur by several mechanisms, including MET amplification … HGF-induced MET activation as a mechanism of attenuated sensitivity to cetuximab in CRC …
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