FLK-1-based minigene vaccines induce T cell-mediated suppression of angiogenesis and tumor protective immunity in syngeneic BALB/c mice
作者： Yunping Luo , Dorothy Markowitz , Rong Xiang , He Zhou , Ralph A. Reisfeld
DOI: 10.1016/J.VACCINE.2006.10.043
关键词: Minigene 、 Kinase insert domain receptor 、 T cell 、 Immunology 、 Cancer research 、 BALB/c 、 Cytotoxic T cell 、 Biology 、 Angiogenesis 、 DNA vaccination 、 Vascular endothelial growth factor
摘要: Abstract Angiogenesis is a rate-limiting step in the development of tumors. Here, we demonstrate that oral minigene DNA vaccines against murine vascular endothelial growth factor receptor-2 (FLK-1), self-antigen overexpressed on proliferating cells tumor vasculature, induced protection tumors different origin syngeneic BALB/c mice. This mediated by CD8 T cells, which specifically kill FLK-1 + resulting marked suppression angiogenesis. More importantly, vaccine proved to be similar efficacy as encoding whole gene. These data suggest provides more flexible alternative gene and will facilitate their future design clinical applications cancer therapy prevention.
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