Effect of age and diabetes on type IV collagen and laminin in human kidney cortex
作者： Tuomo Karttunen , Juha Risteli , Helena Autio–Harmainen , Leila Risteli
DOI: 10.1038/KI.1986.225
关键词: Collagenase 、 Mesangium 、 Basement membrane 、 Proteolytic enzymes 、 Chemistry 、 Hydroxyproline 、 Type IV collagen 、 Radioimmunoassay 、 Endocrinology 、 Laminin 、 Internal medicine
摘要: Specific radioimmunoassays for the 7-S domain of type IV collagen and fragment P1 laminin were used to quantify these basement membrane proteins in human kidney cortex at different ages some patients with diabetes mellitus. The antigens solubilized by treating tissue samples proteolytic enzymes collagenase, trypsin pepsin. Total content (as indicated hydroxyproline concentration) increased age, proportion that could be any enzyme treatment decreased. concentration significantly whereas tended decrease. In one case a I diabetic amounts both exceeded those age matched controls. four II diabetics results comparable other aged cases. distribution was studied using peroxidase-antiperoxidase method. staining intensity thickness mesangium Bowmans capsules, change being more evident. changes pronounced membranes appeared thicker stainings. These indicate material accumulates during aging an alteration takes place composition membranes, increasing decreasing.
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