Life-long dietary restriction modulates the expression of collagens and collagen-binding heat shock protein 47 in aged Fischer 344 rat kidney.

摘要: It has been shown that the expression of HSP47 and collagens is substantially increased in sclerotic/fibrotic process various organs, including kidney. However, factors regulating are not yet clear. In this study, we examined effect dietary restriction for collagen-binding kidneys 6- 24-month-old male Fischer 344 (F 344) rats fed ad libitum or 30% diet-restricted. No significant histological alteration was found 6-month-old diet-restricted rats. Kidneys obtained from freely showed glomerulosclerosis with marked tubulointerstitial damage interstitial fibrosis, while rats, renal remarkably less than those noted rat kidneys. Immunohistochemical analysis an accumulation type I, III IV areas fibrosis old Dietary significantly reduces age. Aging enhanced whereas suppressed its Also, phenotypic alterations mesangial cells (immunopositive α-smooth muscle actin), glomerular epithelial desmin) tubular vimentin) were seen to express HSP47. diminished phenotypically altered Our results suggest associated age-related modulation age-associated sclerosis/fibrosis.