The effects of diabetes mellitus on the pathogenicity of trypanosomosis in rats
作者： Ukwueze Stanley Chigozie , Anene Boniface Maduka
关键词: Red blood cell 、 Mean Survival Time 、 Weight decreasing 、 Blood glucose monitoring 、 Veterinary medicine 、 Alloxan 、 Immunology 、 Body weight 、 Internal medicine 、 Pathogenicity 、 Endocrinology 、 Biology 、 Diabetes mellitus
摘要: Alloxan monohydrate was used to induce diabetes in rats, and then followed post infection with Trypanosoma congolense and Trypanosoma brucei to determine the impact of on course trypanosome infection. Significant (P<0.05) hyperglycaemia occurred alloxan treated rats starting day seven end experiment. Trypanosome did not affect glycaemic status either normal or hyperglycaemic rats. The mean prepatent period (MPP) significantly longer diabetic T. brucei-infected (5.6±0.23 days) than non-diabetics (3.8±0.34 whereas the T. congolense it similar both diabetic (13.1±0.73days) non-diabetic (13.3±0.67 days). levels parasitaemia which were comparable groups increased progressively until death survival time (MST) for (17.2±0.86 (P=0.49) different from that (19.5±1.15 while congolense (34.8±4.15 (P<0.001) (25.7±2.1 days). T. brucei infection diabetics more acute than T. congolense (MST, 17.2±0.86 versus 34.8±4.15 unlike (MST, 19.5±1.15 25.67±2.11 days, P=0.08). red blood cell parameters (PCV, HB RBC) decreased by infections, unaffected but species dependent, being lower brucei than T. congolense-infected A significant decrease percentage body weight gains between controls as a result decreasing effect mellitus. It thus concluded of T. brucei and T. congolense infections altered alloxan-induced may confound results glucose monitoring diagnosis diabetes. Key words: Trypanosoma brucei, Trypanosoma congolense, rat,
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