Dimeric sialyl-Lex expression in gastric carcinoma correlates with venous invasion and poor outcome
作者： Margarida Amado , Fátima Carneiro , Mário Seixas , Henrik Clausen , Manuel Sobrinho–Simões
DOI: 10.1016/S0016-5085(98)70529-3
关键词: Pathological 、 Immunohistochemistry 、 Immunopathology 、 Pathology 、 Gene expression 、 Metastasis 、 Medicine 、 Carcinoma 、 Stomach 、 Survival rate 、 Gastroenterology
摘要: Abstract Background & Aims: High expression of sialyl-Le x in tumors different organs correlates with hematogenous metastasis and adverse outcome. Dimeric gastric carcinoma was evaluated, its prognostic significance within this setting determined. Methods: immunohistochemical 97 carcinomas analyzed using the FH6 monoclonal antibody. Scoring based on percentage immunoreactive cells: negative, low (≤25%), high (>25%). Results: Immunoreactivity observed 45 cases (46.4%), encompassing 27 18 expression, respectively. Significant relationships were found between dimeric venous invasion ( P = 0.0025) histological classification 0.05). No correlation other clinicopathologic features. Patients showing had a significantly shorter survival time than those or no 0.03). By multivariate analysis, pathological TNM (pTNM) staging emerged as independent factors whole series. Within group patients pTNM stages II III, only factor. Conclusions: poor outcome carcinoma. GASTROENTEROLOGY 1998;114:462-470
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