PMX-622 (Polymyxin B-Dextran 70) Does Not Alter In Vitro Activities of 11 Antimicrobial Agents

作者: Peter C. Fuchs , Arthur L. Barry , Steven D. Brown

DOI: 10.1128/AAC.42.10.2765

关键词: AntimicrobialSepsisDextran 70Polymyxin BMicrobiologyIn vitroAntibioticsBiology

摘要: Because of its capacity to neutralize the lethality gram-negative bacterial endotoxic lipopolysaccharides, PMX-622 (polymyxin B bound dextran 70) is being developed for possible adjunctive therapy sepsis. In this study, it was determined that in vitro antimicrobial activity minimal and does not interfere with 11 antibiotics commonly used treat infections.

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