Preparation and antimicrobial evaluation of polyion complex (PIC) nanoparticles loaded with polymyxin B.
作者： Ignacio Insua , Sieta Majok , Anna F.A. Peacock , Anne Marie Krachler , Francisco Fernandez-Trillo
DOI: 10.1016/J.EURPOLYMJ.2016.08.023
关键词:
摘要: Here, we describe novel polyion complex (PIC) particles for the delivery of Polymyxin B (Pol-B), an antimicrobial peptide currently used in clinic as a last resort antibiotic against multidrug-resistant gram-negative bacteria. A range conditions controlled assembly Pol-B with poly(styrene sulphonate) (PSS) has been identified which let us prepare stable colloidal PIC particles. This way, containing different Pol-B:PSS ratios have prepared and their stability under simulated physiological (i.e. pH, osmotic pressure temperature) characterised. Furthermore, preliminary evaluation activity these performed, by monitoring effect on growth Pseudomonas aeruginosa, opportunistic bacterium.
sci-hub.se 参考文章(29)
MatthewE Falagas, SofiaK Kasiakou, Toxicity of polymyxins: a systematic review of the evidence from old and recent studies Critical Care. ,vol. 10, pp. 1- 13 ,(2006) , 10.1186/CC3995
Luccas Missfeldt Sanches, Denise Freitas Siqueira Petri, Letícia Dias Melo Carrasco, Ana Maria Carmona-Ribeiro, None, The antimicrobial activity of free and immobilized poly (diallyldimethylammonium) chloride in nanoparticles of poly (methylmethacrylate) Journal of Nanobiotechnology. ,vol. 13, pp. 58- 58 ,(2015) , 10.1186/S12951-015-0123-3
J.A. Orwa, A. Van Gerven, E. Roets, J. Hoogmartens, Liquid chromatography of polymyxin B sulphate Journal of Chromatography A. ,vol. 870, pp. 237- 243 ,(2000) , 10.1016/S0021-9673(99)00936-X
Patricia Urban, Juan Jose Valle-Delgado, Ernest Moles, Joana Marques, Cinta Diez, Xavier Fernandez-Busquets, Nanotools for the Delivery of Antimicrobial Peptides Current Drug Targets. ,vol. 13, pp. 1158- 1172 ,(2012) , 10.2174/138945012802002302
Brad Spellberg, John G. Bartlett, David N. Gilbert, The Future of Antibiotics and Resistance New England Journal of Medicine. ,vol. 368, pp. 299- 302 ,(2013) , 10.1056/NEJMP1215093
Karyn Hede, Antibiotic resistance: An infectious arms race Nature. ,vol. 509, pp. S2- S3 ,(2014) , 10.1038/509S2A
MARGARET BARNETT, S. R. M. BUSHBY, S. WILKINSON, SODIUM SULPHOMETHYL DERIVATIVES OF POLYMYXINS. British journal of pharmacology and chemotherapy. ,vol. 23, pp. 552- 574 ,(1964) , 10.1111/J.1476-5381.1964.TB01610.X
C. Nathan, Fresh Approaches to Anti-Infective Therapies Science Translational Medicine. ,vol. 4, ,(2012) , 10.1126/SCITRANSLMED.3003081
David L. Dunn, Enhanced Survival During Murine Gram-negative Bacterial Sepsis by Use of a Murine Monoclonal Antibody Archives of Surgery. ,vol. 120, pp. 50- 53 ,(1985) , 10.1001/ARCHSURG.1985.01390250044007
Karolina Alicja Les, Abeer H. A. Mohamed-Ahmed, Sibu Balan, Ji-won Choi, Denis Martin, Vanessa Yardley, Keith Powell, Antony Godwin, Steve Brocchini, Poly(methacrylic acid) complexation of amphotericin B to treat neglected diseases Polymer Chemistry. ,vol. 5, pp. 1037- 1048 ,(2014) , 10.1039/C3PY01051A