Selective liver X receptor modulators (SLiMs): What use in human health?
作者： Emilie Viennois , Kevin Mouzat , Julie Dufour , Laurent Morel , Jean-Marc Lobaccaro
DOI: 10.1016/J.MCE.2011.08.036
关键词: Fatty acid synthesis 、 Transcription factor 、 Nuclear receptor 、 Lipid metabolism 、 Receptor 、 Biology 、 Homeostasis 、 Glucose homeostasis 、 Pharmacology 、 Liver X receptor 、 Biochemistry 、 Molecular biology 、 Endocrinology
摘要: Liver X receptors (LXR) are members of the nuclear receptor family. As activated transcription factors, their putative association with human diseases makes them promising pharmacological targets because large potential to develop ligands. LXR mainly considered as intracellular cholesterol "sensors" whose activation leads decreased plasma cholesterol. They also modulate numerous physiological functions: fatty acid synthesis and metabolism, glucose homeostasis, steroidogenesis, immunity, neurological homeostasis. LXR-deficiency in mouse results several phenotypes mimicking pathological conditions humans. This review will be focused on various natural synthetic agonists antagonists. Putative clinical including atherosclerosis, diabetes, Alzheimer's disease, skin disorders, cancer covered.
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