Anti-Fibrosis Effect of Scutellarin via Inhibition of Endothelial–Mesenchymal Transition on Isoprenaline-Induced Myocardial Fibrosis in Rats

摘要: Scutellarin (SCU) is the major active component of breviscapine and has been reported to be capable decreasing myocardial fibrosis. The aim present study investigate whether SCU treatment attenuates isoprenaline-induced fibrosis mechanisms its action. Rats were injected subcutaneously with isoprenaline (Iso) induce rats in groups intraperitoneally infused (10 mg·kg−1·d−1 or 20 mg·kg−1·d−1, for 14 days). Post-treatment, cardiac functional measurements left right ventricular weight indices (LVWI RVWI, respectively) analysed. Pathological alteration, expression type I III collagen, Von Willebrand factor, α-smooth muscle actin, cluster differentiation-31 (CD31), Notch signalling proteins (Notch1, Jagged1 Hes1) examined. administration resulted a significant improvement function decrease indices; reduced fibrous tissue proliferation; levels collagen; increased microvascular density; decreased actin CD31, Notch1, Hes1 rats. Our results suggest that prevents via inhibition endothelial-mesenchymal transition potentially, which may associated pathway.