The promoting angiogenesis and anti-inflammation effect of scutellarin on polyglycolic acid scaffold of balb/c mice model.
作者： Jing-Yuan Ma , Wei-Wen Jiang , Zeng-Tong Zhou , Jing-Min Li , Hai-Yan Wang
DOI: 10.1080/10286020802361255
关键词:
摘要: Engineering artificial implantable tissues require rapid induction of angiogenesis to meet the significant oxygen and nutrient demands cell during tissue repair. In this study, we investigated role a Chinese medicine, scutellarin (1), in engineering scaffold balb/c mice model. The trial groups were given an intraperitoneal injection 1 at 20, 60, 100 mg/kg per ml, respectively. implanted samples retrieved week month post transplantation. Angiogenesis response polyglycolic acid (PGA) was evaluated by histopathological immunohistochemical methods. expression levels vascular endothelial growth factor (VEGF) determined RT-PCR. results showed that density neocapillaries PGA enhanced basic fibroblast (bFGF) week. At month, only 60 ml continuingly kept neocapillaries. inflammatory cells significantly less 100...
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