Gastroprotective effect of desmosdumotin C isolated from Mitrella kentii against ethanol-induced gastric mucosal hemorrhage in rats: possible involvement of glutathione, heat-shock protein-70, sulfhydryl compounds, nitric oxide, and anti-Helicobacter pylori activity.

作者: Heyam Mohamed Sidahmed Heyam Mohamed Sidahmed , Ainnul Hamidah Azizan Ainnul Hamidah Azizan , Syam Mohan Syam Mohan , Mahmood Ameen Abdulla Mahmood Ameen Abdulla , SI Abdelwahab

DOI: 10.1186/1472-6882-13-183

关键词: ToxicityPharmacologyGlutathioneAntioxidantHsp70MedicineBioactive compoundHelicobacter pyloriBiochemistryMalondialdehydeNitric oxide

摘要: … A potent antibacterial compound is one that shows an MIC value of less than or equal to 250 [71]. To evaluate the antimicrobial activity of DES, the compound was examined against H …

参考文章(72)
Masaru Odashima, Michiro Otaka, Mario Jin, Noriaki Konishi, Toshihiro Sato, Sayuri Kato, Tamotsu Matsuhashi, Chieko Nakamura, Sumio Watanabe, Induction of a 72-kDa Heat-Shock Protein in Cultured Rat Gastric Mucosal Cells and Rat Gastric Mucosa by Zinc l-Carnosine Digestive Diseases and Sciences. ,vol. 47, pp. 2799- 2804 ,(2002) , 10.1023/A:1021029927386
M Dorababu, R Tandon, H D Khanna, R K Goel, Oxidative stress and antioxidants status in peptic ulcer and gastric carcinoma. Indian journal of physiology and pharmacology. ,vol. 48, pp. 115- 118 ,(2004)
Liriane Baratella-Evêncio, Sílvio Henrique de Freitas, Renata Gebara Sampaio Dória, Joaquim Evêncio Neto, Fábio de Souza Mendonça, Lázaro Manoel de Camargo, ASPECTOS CLÍNICOS E PATOLÓGICOS DE UM SURTO DE FOTOSSENSIBILIZAÇÃO HEPATÓGENA EM OVINOS PELA INGESTÃO DE Brachiaria decumbens (Gramineae) NO MUNICÍPIO DE CUIABÁ, MATO GROSSO Ciência Animal Brasileira. ,vol. 9, pp. 1034- 1041 ,(2008) , 10.5216/CAB.V9I4.525
Hiroyuki Mutoh, Hideyuki Hiraishi, Shinichi Ota, Haruhiko Yoshida, Kevin J. Ivey, Akira Terano, Tsuneaki Sugimoto, Protective role of intracellular glutathione against ethanol-induced damage in cultured rat gastric mucosal cells Gastroenterology. ,vol. 98, pp. 1452- 1459 ,(1990) , 10.1016/0016-5085(90)91075-H
Katrina M. Miranda, Michael G. Espey, David A. Wink, A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide. ,vol. 5, pp. 62- 71 ,(2001) , 10.1006/NIOX.2000.0319
Thiago de Mello Moraes, Clenilson Martins Rodrigues, Hélio Kushima, Tais Maria Bauab, Wagner Villegas, Cláudia Helena Pellizzon, Alba Regina Monteiro Souza Brito, Clélia Akiko Hiruma-Lima, Hancornia speciosa: indications of gastroprotective, healing and anti-Helicobacter pylori actions. Journal of Ethnopharmacology. ,vol. 120, pp. 161- 168 ,(2008) , 10.1016/J.JEP.2008.08.001
Francisco A Oliveira, Gerardo M Vieira-Júnior, Mariana H Chaves, Fernanda RC Almeida, Mariana G Florêncio, Roberto CP Lima Jr, Regilane M Silva, Flavia A Santos, Vietla SN Rao, None, Gastroprotective and anti-inflammatory effects of resin from Protium heptaphyllum in mice and rats. Pharmacological Research. ,vol. 49, pp. 105- 111 ,(2004) , 10.1016/J.PHRS.2003.09.001
Elisângela Saturnino de Souza Almeida, Valdir Cechinel Filho, Rivaldo Niero, Bruna Kurz Clasen, Sikiru Olaitan Balogun, Domingos Tabajara de Oliveira Martins, Pharmacological mechanisms underlying the anti-ulcer activity of methanol extract and canthin-6-one of Simaba ferruginea A. St-Hil. in animal models. Journal of Ethnopharmacology. ,vol. 134, pp. 630- 636 ,(2011) , 10.1016/J.JEP.2011.01.009
Kaushik Biswas, Uday Bandyopadhyay, Ishita Chattopadhyay, Archana Varadaraj, Esahak Ali, Ranajit K. Banerjee, A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical Journal of Biological Chemistry. ,vol. 278, pp. 10993- 11001 ,(2003) , 10.1074/JBC.M210328200