Soluble Non-Cross-Linked Peptidoglycan Polymers Stimulate Monocyte-Macrophage Inflammatory Functions
作者： M R Gold , C L Miller , R I Mishell
DOI: 10.1128/IAI.49.3.731-741.1985
关键词: Gram-positive bacteria 、 Microbiology 、 Interleukin 、 Biology 、 Plasminogen activator 、 Macrophage 、 Peptidoglycan 、 Monocyte 、 Inflammation 、 Biochemistry 、 Colony-stimulating factor
摘要: Abstract Soluble non-cross-linked peptidoglycan polymers are released by gram-positive bacteria when beta-lactam antibiotics administered to humans. In this report, we show that type of can stimulate monocyte-macrophage functions cause inflammation. Non-cross-linked from penicillin-treated Streptococcus faecium were purified and shown the production interleukin 1 human monocytes colony-stimulating factors a murine macrophage cell line. addition, release plasminogen activator was inhibited soluble peptidoglycan. These in vitro results suggest prolonged treatment with antibiotics, causing peptidoglycan, may result 1-mediated inflammatory reactions, excessive granulocytes, increased fibrin deposition.
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