Granuloma formation by synthetic bacterial cell wall fragment: muramyl dipeptide.

摘要: A synthetic muramyl dipeptide, N-acetylmuramyl-L-alanyl-D-isoglutamine, which possesses the same structure as that of a part peptidoglycan monomer wax D tubercle bacilli or bacterial cell walls was found to induce, when injected in water-in-oil emulsion, massive granulomas often accompanying abscesses site injection and draining lymph nodes guinea pigs rats. The were composed mainly epithelioid cells 2 weeks after indistinguishable from those induced by bacilli. rats less mature than pigs. Allergic reaction appeared play no important role development muarmyl dipeptide-induced granuloma. Images