Role of P2X7 Receptor in an Animal Model of Mania Induced by D-Amphetamine

摘要: The objective of this study was to explore the association between P2X7 purinergic receptor (P2X7R) and neuroinflammation using a preclinical model acute bipolar mania. We analyzed modulatory effects P2X7R agonist (3′-O-(4-benzoyl)benzoyl-adenosine 5′-triphosphate, BzATP) antagonists (brilliant blue, BBG 3-[[5-(2,3 dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride, A438079) on assessments related behavior (locomotor activity), (interleukin-1 beta, IL-1β; tumor necrosis factor alpha, TNF-α; interleukin- 6, IL-6), oxidative stress (thiobarbituric acid reactive substances, TBARS) neuroplasticity (brain-derived neurotrophic factor, BDNF) markers in pharmacological mania induced by chronic treatment with D-amphetamine (AMPH) (2 mg/kg) mice. An apparent lack responsiveness AMPH observed terms locomotor activity animals blocked or genetic deletion knockout (P2X7R−/−) Likewise, participated AMPH-induced increase proinflammatory excitotoxic environment, as demonstrated reversal IL-1β, TNF-α, TBARS levels caused blocking. Our results support hypothesis that plays role mania, which could explain altered behavior. present data suggest may be therapeutic target reported disorder.