Regulation of immune responses. I. Effects of cyclic AMP and cyclic GMP on immune induction.

摘要: Abstract Agents that raise intracellular cAMP levels (dibutyryl cyclic AMP, aminophylline, adenosine and butyric acid) increase the magnitude of an in vitro primary humoral immune response when added at 10 −3 M during first 12 hr a 108 culture. Under same conditions, cGMP has no direct effect but inhibits cAMP-mediated stimulation. DbcAMP (10 or −4 ), present from 0 to hr, also increases number cytotoxic lymphocytes CBA/J (H-2 k ) spleen cell cultures stimulated one-way mixed lymphocyte reaction with DBA/2J d cells. The dbcAMP is antigen-dependent both cell-mediated immunity antigen-specific case responses.