Candida infective endocarditis: An observational cohort study with a focus on therapy

摘要: Candida infective endocarditis is a rare disease with high mortality rate. Our understanding of this infection derived from case series, reports, and small prospective cohorts. The purpose study was to evaluate the clinical features use different antifungal treatment regimens for endocarditis. This cohort based on 70 cases International Collaboration Endocarditis (ICE)-Prospective Cohort Study ICE-Plus databases collected between 2000 2010. majority infections were acquired nosocomially (67%). Congestive heart failure (24%), prosthetic valve (46%), previous (26%) common comorbidities. Overall high, 36% in hospital 59% at 1 year. On univariate analysis, older age, baseline, persistent candidemia, nosocomial acquisition, as complication, intracardiac abscess associated higher mortality. Mortality not affected by surgical therapy or choice agent. A subgroup analysis performed 33 patients whom specific information available. In subgroup, 11 received amphotericin B-based 14 echinocandin-based therapy. Despite percentage echinocandin group, rates similar two groups. conclusion, rate that impacted adjunctive intervention. Additionally, effective analysis.