Histological grading of therapy induced regression in squamous cell carcinomas of the oral cavity: A morphological and immunohistochemical study

摘要: Summary Squamous cell carcinomas in the oral cavity and oropharynx were diagnosed 84 patients. After verification by biopsy, 79 of these patients treated preoperatively with mitomycin C 5-fluro-uracil, radiated operated 3–5 weeks later. The effectiveness adjuvant preoperative radio-chemotherapy was evaluated histologically. Serial sections entire tumor specimen investigated percentage vital cancerous tisue total area assessed. Regression classified into four grades. Grades I II regarded as good response to radio-chemotherapy, while grades III IV stood for bad or no response. Morphologically questionable residual infiltrates could be clarified immunohistochemical methods antibodies against vimentin, desmin Lu-5. histological assessment regression grade specimens allows a clinically relevant, morphologically exact reproducible evaluation effect radiochemotherapy.