Complex Pharmacology of Free Fatty Acid Receptors

作者: Graeme Milligan , Bharat Shimpukade , Trond Ulven , Brian D. Hudson

DOI: 10.1021/ACS.CHEMREV.6B00056

关键词: AgonismFree fatty acid receptor 2G protein-coupled receptorAllosteric regulationReceptorChemistryPharmacologyBinding siteFatty acid

摘要: … of the complex pharmacology of receptors that recognize and are … (n)–3 fatty acid has its first unsaturation three carbon atoms … of agonist-independent signal transduction and therefore …

参考文章(392)
Stephen J. Briddon, Barrie Kellam, Stephen J. Hill, Design and Use of Fluorescent Ligands to Study Ligand–Receptor Interactions in Single Living Cells Methods in Molecular Biology. ,vol. 746, pp. 211- 236 ,(2011) , 10.1007/978-1-61779-126-0_11
Xiu-Lei Mo, Hong-Kui Wei, Jian Peng, Ya-Xiong Tao, Free fatty acid receptor GPR120 and pathogenesis of obesity and type 2 diabetes mellitus Progress in Molecular Biology and Translational Science. ,vol. 114, pp. 251- 276 ,(2013) , 10.1016/B978-0-12-386933-3.00007-8
Hui Huang, Meng-Hong Dai, Ya-Xiong Tao, Physiology and therapeutics of the free fatty acid receptor GPR40. Progress in Molecular Biology and Translational Science. ,vol. 121, pp. 67- 94 ,(2014) , 10.1016/B978-0-12-800101-1.00003-X
Dong-Soon Im, Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages. European Journal of Pharmacology. ,vol. 785, pp. 36- 43 ,(2016) , 10.1016/J.EJPHAR.2015.03.094
Jonas Dehairs, Rita Derua, Natalia Rueda-Rincon, Johannes V. Swinnen, Lipidomics in drug development. Drug Discovery Today: Technologies. ,vol. 13, pp. 33- 38 ,(2015) , 10.1016/J.DDTEC.2015.03.002
Muhammad Zahid Khan, Ling He, The role of polyunsaturated fatty acids and GPR40 receptor in brain. Neuropharmacology. ,vol. 113, pp. 639- 651 ,(2017) , 10.1016/J.NEUROPHARM.2015.05.013
Ihor Zahanich, Ivan Kondratov, Vasyl Naumchyk, Yuri Kheylik, Maxim Platonov, Sergey Zozulya, Mikhail Krasavin, Phenoxymethyl 1,3-oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty acid receptor 1 (GPR40) Bioorganic & Medicinal Chemistry Letters. ,vol. 25, pp. 3105- 3111 ,(2015) , 10.1016/J.BMCL.2015.06.018
Terrence P. Kenakin, Michael William Lutz, Quantitative Molecular Pharmacology and Informatics in Drug Discovery : John Wiley. ,(1999)
Kazuo Nakamoto, Fuka Aizawa, Takashi Nishinaka, Shogo Tokuyama, Regulation of prohormone convertase 2 protein expression via GPR40/FFA1 in the hypothalamus European Journal of Pharmacology. ,vol. 762, pp. 459- 463 ,(2015) , 10.1016/J.EJPHAR.2015.06.013
Kaori Fukushima, Eri Yamasaki, Shuhei Ishii, Ayaka Tomimatsu, Kaede Takahashi, Miku Hirane, Nobuyuki Fukushima, Kanya Honoki, Toshifumi Tsujiuchi, Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells. Biochemical and Biophysical Research Communications. ,vol. 465, pp. 512- 515 ,(2015) , 10.1016/J.BBRC.2015.08.050