Exercise increases serum endostatin levels in female and male patients with diabetes and controls

摘要: Background: Type 2 diabetes mellitus (T2DM) is often associated with atherosclerotic changes in coronary vessels, most notably plaques. The angiostatic parameter endostatin able to inhibit angiogenesis tissue as well plaques and therefore plays an important role physiological pathological neovascularisation. aim of the present study was investigate sex-specific differences influence exercise on circulating levels patients suffering from diabetes, control subjects. Methods: In total, 42 T2DM-patients 45 subjects were investigated. They underwent a graded physical stress test (ergometry). Serum measured venous blood at rest directly after reaching maximum workload. Results: Females showed significantly higher baseline measurements compared men, independently their underlying disease. both female male lower controls. Both groups sexes significant increase stress, whereas extent endostatin-increase between 10.59-15.05%. Conclusion: Middle-aged healthy individuals serum males, suggesting hormonal amounts. Exercise-induced also observable T2DM. Concerning vascularisation, T2DM might be advantageous. plaque stability, prejudicial. Trial registration: Clinical Registration-URL: http://clinicaltrials.gov/ct2/results?term=NCT01165515