Effects of vitamin B6 deficiency and repletion on the uptake of steroid hormones into uterus slices and isolated liver cells of rats.
作者： David A. Bender , Kweku Ghartey-Sam , Amerjit Singh
DOI: 10.1079/BJN19890149
关键词: Vitamin 、 Receptor 、 Internal medicine 、 Steroid hormone 、 Pyridoxal phosphate 、 Pyridoxine 、 Biology 、 Hormone 、 Steroid 、 Endocrinology 、 Testosterone
摘要: 1. In vitro, pyridoxal phosphate extracts steroid-hormone receptors from tight nuclear binding (Cidlowski & Thanassi, 1981); in vitamin B6-deficient rats there is increased and prolonged accumulation of oestradiol the uterus testosterone prostate, associated with enhanced biological responsiveness these target tissues to steroid hormone action (Symes et al. 1984; Bowden 1986). 2. Slices accumulated more [3H]oestradiol than did tissue repleted animals. Acute repletion B6 (0.5-1 h before killing) further uptake steroid. 3. Isolated hepatocytes [3H]dexamethasone cells Pre-incubation resulted a increase 4. The results suggest that addition putative role releasing steroid-hormone-receptor complexes 1981), deficiency may also concentration or enzymes other steroid-binding proteins tissues.
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