MR temperature imaging of nanoshell mediated laser ablation.
作者： R. Jason Stafford , Anil Shetty , Andrew M. Elliott , Jon A. Schwartz , Glenn P. Goodrich
DOI: 10.3109/02656736.2011.614671
关键词: Pathology 、 Biomedical engineering 、 Gold nanoshells 、 Microscopy 、 Nanoparticle 、 Nanoshell 、 Proton resonance frequency 、 Laser ablation 、 Magnetic resonance imaging 、 Materials science 、 Laser
摘要: Minimally invasive thermal therapy using high-power diode lasers is an active area of clinical research. Gold nanoshells (AuNS) can be tuned to absorb light in the range used for laser ablation and may facilitate more conformal tumor heating sparing normal tissue via enhanced specific heating. This concept was investigated a xenograft model prostate cancer (PC-3) MR temperature imaging (MRTI) 1.5T scanner characterize spatiotemporal distribution resulting from nanoparticle mediated Tumors with without intravenously injected AuNS were exposed external 808 nm 180 sec at 4 W/cm2 under real-time monitoring proton resonance frequency shift based MRTI. Microscopy indicated that these nanoparticles (140–150 nm) accumulated passively remained close microvasculature. MRTI measured statistically significant (p < 0.001) increase maximum cortex (mean = 21 ± 7°C) +A...
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