Influenza virus vaccination in kidney transplant recipients: serum antibody response to different immunosuppressive drugs.
作者： Mauro J.C. Salles , Yvoty A.S. Sens , Lucy S.V. Boas , Clarisse M. Machado
DOI: 10.1111/J.1399-0012.2009.01095.X
关键词: Seroconversion 、 Vaccination 、 Kidney transplantation 、 Trivalent influenza vaccine 、 Influenza vaccine 、 Immunology 、 Influenza A virus 、 Mycophenolic acid 、 Antibody titer 、 Medicine
摘要: Salles MJC, Sens YAS, Boas LSV, Machado CM. Influenza virus vaccination in kidney transplant recipients: serum antibody response to different immunosuppressive drugs. Clin Transplant 2010: 24: E17–E23. © 2009 John Wiley & Sons A/S. Abstract: Introduction: This study prospectively accessed the immune inactivated influenza vaccine renal recipients receiving either azathioprine or mycophenolate mofetil (MMF). Side effects were investigated. Methods: Sixty-nine patients received one dose of trivalent vaccine. Antihemagglutinin (HI) against each strain was measured before and six months after vaccination. Results: Geometric mean HI titers for H1N1 H3N2 strains increased from 2.57 2.44 13.45 (p = 0.001) 7.20 (p < 0.001), respectively. Pre- post-vaccination protection rates 8.7% 49.3% (p < 0.001); 36.3% (p < 0.001) seroconversion 36% 25.3%, There no B. The use MMF reduced rate when compared with azathioprine, subjects transplanted less than 87 months also had inferior response. Adverse events mild there change on function post-vaccination. Conclusion: Renal vaccinated responded production A strains, but not Use shorter time transplantation decreased
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