Adenovirus RID complex enhances degradation of internalized tumour necrosis factor receptor 1 without affecting its rate of endocytosis.
作者： Y. Rebecca Chin , Marshall S. Horwitz
关键词: Biology 、 Tumor necrosis factor alpha 、 Endocytosis 、 Adenoviridae 、 Virology 、 Cytokine 、 Receptor 、 Biotinylation 、 Endosome 、 Cell
摘要: The receptor internalization and degradation (RID) complex of adenovirus plays an important role in modulating the immune response by downregulating surface levels tumour necrosis factor 1 (TNFR1), thereby inhibiting NF-κB activation. Total cellular content TNFR1 is also reduced presence RID, which can be inhibited treatment with lysosomotropic agents. In this report, biotinylation experiments revealed that, although RID were able to form a on cell surface, rate endocytosis was not affected RID. However, internalized enhanced significantly Therefore, these data suggest that downregulates altering fate becomes associated at plasma membrane, probably promoting its sorting into endosomal/lysosomal compartments.
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