Regulation of sperm flagellar motility by calcium and cAMP-dependent phosphorylation.

摘要: There is substantial evidence that cAMP-dependent phosphorylation involved in the activation of motility spermatozoa as they are released from storage male reproductive tract. This includes observations vivo can be inhibited by protein kinase inhibitors, reversed phosphatase treatment demembranated spermatozoa, and associated with sperm proteins, have not been activated vitro phosphorylation. Activation often triggered conditions increase intracellular pH, but relevance this to under natural steps between pH cAMP fully established. The relationships changes substrates for axonemal function still unknown. Sperm chemotaxis egg secretions widespread; sea urchin Arbacia, jelly peptide resact has identified a chemoattractant. Response chemoattractants involves asymmetry flagellar bending waves, similar produced increases [Ca++]. Temporal receptor occupancy might lead transient [Ca++] bending, many links hypothetical sequence remain Both these signalling systems offer immediate opportunities investigations biochemical pathways leading easily assayable biological responses. However, complications resulting interactions two need considered.