Assessment of PTEN tumor suppressor activity in nonmammalian models : the year of the yeast
作者： V J Cid , I Rodríguez-Escudero , A Andrés-Pons , C Romá-Mateo , A Gil
DOI: 10.1038/ONC.2008.240
关键词: Unicellular organism 、 Genetics 、 Model organism 、 Yeast 、 Biology 、 Saccharomyces cerevisiae 、 PI3K/AKT/mTOR pathway 、 PTEN 、 Phenotype 、 Cell biology 、 Tumor suppressor gene
摘要: Model organisms have emerged as suitable and reliable biological tools to study the properties of proteins whose function is altered in human disease. In case PI3K PTEN cancer-related proteins, several vertebrate invertebrate models, including mouse, fly, worm amoeba, been exploited obtain relevant functional information that has conserved from these humans along evolution. The yeast Saccharomyces cerevisiae an eukaryotic unicellular organism lacks a canonical mammalian-like PI3K/PTEN pathway PIP3 physiological second messenger, PIP2 being essential for its life. mammalian can be reconstituted S. cerevisiae, generating growth alteration phenotypes easily monitored perform vivo analysis molecular constituents this pathway. Here, we review current nonmammalian model systems function, summarize our knowledge orthologs species propose sensitive sensor oncogenicity tumor suppressor activity.
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Paul Kaloudis, Kathrin H. Kirsch, Nikola P. Pavletich, Hidesaburo Hanafusa, Maria-Magdalena Georgescu, Haijuan Yang, Stabilization and Productive Positioning Roles of the C2 Domain of PTEN Tumor Suppressor Cancer Research. ,vol. 60, pp. 7033- 7038 ,(2000)
Joanne A. Fox, Karen Ung, Sonia G. Tanlimco, Frank R. Jirik, Disruption of a Single Pten Allele Augments the Chemotactic Response of B Lymphocytes to Stromal Cell-Derived Factor-1 Journal of Immunology. ,vol. 169, pp. 49- 54 ,(2002) , 10.4049/JIMMUNOL.169.1.49
Walter von Stein, Andreas Ramrath, Alexandra Grimm, Marion Müller-Borg, Andreas Wodarz, Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling Development. ,vol. 132, pp. 1675- 1686 ,(2005) , 10.1242/DEV.01720
Stuart Tugendreich, Ed Perkins, Joe Couto, Peter Barthmaier, Dongxu Sun, Shawn Tang, Suzana Tulac, Allen Nguyen, Elaine Yeh, Amy Mays, Ellen Wallace, Tom Lila, Dave Shivak, Mark Prichard, Laura Andrejka, Raymond Kim, Teri Melese, A Streamlined Process to Phenotypically Profile Heterologous cDNAs in Parallel Using Yeast Cell-Based Assays Genome Research. ,vol. 11, pp. 1899- 1912 ,(2001) , 10.1101/GR.191601
Shuang-Yin Han, Hideaki Kato, Shunsuke Kato, Takao Suzuki, Hiroyuki Shibata, Seiichi Ishii, Ken-ichi Shiiba, Seiki Matsuno, Ryunosuke Kanamaru, Chikashi Ishioka, None, Functional Evaluation of PTEN Missense Mutations Using in Vitro Phosphoinositide Phosphatase Assay Cancer Research. ,vol. 60, pp. 3147- 3151 ,(2000)
Rafael Pulido, Rob Hooft van Huijsduijnen, Protein tyrosine phosphatases: dual‐specificity phosphatases in health and disease FEBS Journal. ,vol. 275, pp. 848- 866 ,(2008) , 10.1111/J.1742-4658.2008.06250.X
Walter Brogiolo, Ernst Hafen, Tian Xu, Da Ming Li, Wufan Tao, He Huang, Hong Sun, Christopher J. Potter, PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development. ,vol. 126, pp. 5365- 5372 ,(1999) , 10.1242/DEV.126.23.5365
Jie-Oh Lee, Haijuan Yang, Maria-Magdalena Georgescu, Antonio Di Cristofano, Tomohiko Maehama, Yigong Shi, Jack E Dixon, Pier Pandolfi, Nikola P Pavletich, Crystal Structure of the PTEN Tumor Suppressor: Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association Cell. ,vol. 99, pp. 323- 334 ,(1999) , 10.1016/S0092-8674(00)81663-3
Wuzhou Wan, Haixia Zou, Ronghua Sun, Ying Liu, Jingna Wang, Dalong Ma, Ning Zhang, Investigate the role of PTEN in chemotaxis of human breast cancer cells. Cellular Signalling. ,vol. 19, pp. 2227- 2236 ,(2007) , 10.1016/J.CELLSIG.2007.06.007
Ivo Pedruzzi, Frédérique Dubouloz, Elisabetta Cameroni, Valeria Wanke, Johnny Roosen, Joris Winderickx, Claudio De Virgilio, TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0. Molecular Cell. ,vol. 12, pp. 1607- 1613 ,(2003) , 10.1016/S1097-2765(03)00485-4