Stabilization and Productive Positioning Roles of the C2 Domain of PTEN Tumor Suppressor
作者： Paul Kaloudis , Kathrin H. Kirsch , Nikola P. Pavletich , Hidesaburo Hanafusa , Maria-Magdalena Georgescu
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摘要: … domain and their relevance for tumor growth. To discriminate … When tumor-derived mutations in the loops that connect the … but had variable effects on the phosphatase activity and tumor …
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researchgate.net 参考文章(35)
H-J. Su Huang, Webster K. Cavenee, Frank B. Furnari, The Phosphoinositol Phosphatase Activity of PTEN Mediates a Serum-sensitive G1 Growth Arrest in Glioma Cells Cancer Research. ,vol. 58, pp. 5002- 5008 ,(1998)
Marian S. Blazes, Kathleen R. Cho, Steven I. Wang, Ramon Parsons, Shikha Bose, Lora Hedrick Ellenson, Hironori Tashiro, Jing Li, Rong Wu, Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Research. ,vol. 57, pp. 3935- 3940 ,(1997)
Christa Miliaresis, Christa Miliaresis, Nicholas Tonks, Nicholas Tonks, Ramon Parsons, Ramon Parsons, Laura Simpson, Laura Simpson, Michael P. Myers, Michael P. Myers, Jing Li, Jing Li, Michelle Takahashi, Michelle Takahashi, The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Research. ,vol. 58, pp. 5667- 5672 ,(1998)
Faina Bogomolniy, Esther Rhei, Patrick I. Borgen, Lan Kang, Mark G. Federici, Jeff Boyd, Mutation Analysis of the Putative Tumor Suppressor Gene PTEN/MMAC1 in Primary Breast Carcinomas Cancer Research. ,vol. 57, pp. 3657- 3659 ,(1997)
Sung-Gil Chi, Hyo-Jong Kim, Bum-Joon Park, Hyun-Jung Min, Jae-Hoon Park, Youn-Wha Kim, Seok-Ho Dong, Byung-Ho Kim, Jung-Il Lee, Young-Woon Chang, Rin Chang, Woo-Kap Kim, Moon-Ho Yang, Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease☆☆☆ Gastroenterology. ,vol. 115, pp. 1084- 1089 ,(1998) , 10.1016/S0016-5085(98)70078-2
R Ashfaq, J S Martin, E Forgacs, W M Lin, D P Warshal, I T Yeh, C Y Muller, Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. Clinical Cancer Research. ,vol. 4, pp. 2577- 2583 ,(1998)
Jie-Oh Lee, Haijuan Yang, Maria-Magdalena Georgescu, Antonio Di Cristofano, Tomohiko Maehama, Yigong Shi, Jack E Dixon, Pier Pandolfi, Nikola P Pavletich, Crystal Structure of the PTEN Tumor Suppressor: Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association Cell. ,vol. 99, pp. 323- 334 ,(1999) , 10.1016/S0092-8674(00)81663-3
Takashi Kohno, Mina Takahashi, Ryokuhei Manda, Jun Yokota, Inactivation of thePTEN/MMAC1/TEP1 gene in human lung cancers Genes, Chromosomes and Cancer. ,vol. 22, pp. 152- 156 ,(1998) , 10.1002/(SICI)1098-2264(199806)22:2<152::AID-GCC10>3.0.CO;2-S
Lars-Oliver Essen, Olga Perisic, Robert Cheung, Matilda Katan, Roger L. Williams, Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta. Nature. ,vol. 380, pp. 595- 602 ,(1996) , 10.1038/380595A0
Eva Forgacs, Eric J Biesterveld, Yoshitaka Sekido, Kwun Fong, Sabeeha Muneer, Ignacio I Wistuba, Sara Milchgrub, Ruth Brezinschek, Arvind Virmani, Adi F Gazdar, John D Minna, Mutation analysis of the PTEN/MMAC1 gene in lung cancer Oncogene. ,vol. 17, pp. 1557- 1565 ,(1998) , 10.1038/SJ.ONC.1202070