PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development.

摘要: Mutations in the tumor suppressor gene PTEN (MMAC1/TEP1) are associated with a large number of human cancers and several autosomal-dominant disorders. Mice mutant for die at early embryonic stages fibroblasts display decreased sensitivity to cell death. Overexpression different mammalian tissue culture cells affects various processes including proliferation, death migration. We have characterized Drosophila present evidence that both inactivation overexpression affect size, while also inhibits cycle progression mitosis promotes during eye development context-dependent manner. Furthermore, we shown acts insulin signaling pathway all signals from receptor can be antagonized by either or PTEN, suggesting potential means alleviating symptoms altered signaling.