Rhythmicity in arterial smooth muscle.

摘要: Many arteries and arterioles exhibit rhythmical contractions which are synchronous over considerable distances. This vasomotion is likely to assist in tissue perfusion especially during periods of altered metabolism or pressure. While the mechanism underlying vascular rhythmicity has been investigated for many years, it only recently, with advent imaging techniques visualizing intracellular calcium release, that significant advances have made. These methods, when combined mechanical electrophysiological recordings, demonstrated rhythm depends critically on released from stores within smooth muscle cells cell coupling via gap junctions synchronize oscillations release amongst adjacent cells. these factors common all vessels studied date, contribution voltage-dependent channels endothelium varies different vessels. The basic activity thus differs its counterpart non-vascular muscle, where specific networks pacemaker generate electrical potentials drive otherwise quiescent