Circulating hepatocyte membrane-specific autoantibodies in chronic active hepatitis type B. Relation to virus replication activity and liver cell necrosis.
作者： Riccardo Meliconi , Mario Baraldini , Alfredo Alberti , Flavia Bortolotti , Giuseppe Realdi
DOI: 10.1007/BF01347294
关键词: Autoantibody 、 Liver biopsy 、 Hepatitis B 、 Hepatology 、 Antibody 、 Pathology 、 Liver cell 、 Hepatocyte 、 Immunology 、 Hepatitis 、 Medicine 、 Internal medicine
摘要: Sera from two groups of untreated HBsAG-positive patients with chronic active hepatitis on liver biopsy were tested for antibodies to cell membrane antigens (liver-specific protein, LSP; and antigen, LM-Ag). Among the 14 HBeAg-positive cases, seven (50%) positive anti-LSP, whereas only (13%) 15 anti-HBe-positive cases circulated this antibody. Liver autoantibody (LMA) was detected in sera delta-positive (1 HBeAg 1 anti-HBe positive). Anti-LSP-positive presented transaminase values significantly higher than those negative cases. Our data do not support hypothesis that a liver-specific autoimmune mechanism plays significant role immunopathogenesis necrosis type B. The relationship between hepatocyte anti-LSP antibody response is confirmed.
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sci-hub.se 参考文章(25)
F Miglio, G F Stefanini, G Gasbarrini, R Meliconi, M Baraldini, M Garagnani, M V Stancari, Occurrence and significance of IgG liver membrane autoantibodies (LMA) in chronic liver diseases of different aetiology. Clinical and Experimental Immunology. ,vol. 51, pp. 565- 571 ,(1983)
P J Jenkins, B Portmann, D Vergani, R Williams, A P Mowat, G M Vergani, A L Eddleston, Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg-negative chronic active hepatitis. Clinical and Experimental Immunology. ,vol. 38, pp. 16- 21 ,(1979)
F Miglio, G F Stefanini, A Alberti, F Bortolotti, R Meliconi, M Baraldini, G Realdi, A Facchini, P Amoroso, Antibodies against human liver-specific protein (LSP) in acute and chronic viral hepatitis types A, B and non-A, non-B. Clinical and Experimental Immunology. ,vol. 46, pp. 382- 390 ,(1981)
A. Alberti, S. Diana, G.H. Scullard, A.L.W.F. Eddleston, Roger Williams, Full and empty Dane particles in chronic hepatitis B virus infection: Relation to hepatitis B e antigen and presence of liver damage Gastroenterology. ,vol. 75, pp. 869- 874 ,(1978) , 10.1016/0016-5085(78)90472-9
A Alberti, M Mondelli, B Portmann, D Vergani, R Williams, G M Vergani, A L Eddleston, Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: Evidence that T cells are directed against HBV core antigen expressed on hepatocytes Journal of Immunology. ,vol. 129, pp. 2773- 2778 ,(1982)
Paul M. Kaplan, Richard L. Greenman, John L. Gerin, Robert H. Purcell, William S. Robinson, DNA Polymerase Associated with Human Hepatitis B Antigen Journal of Virology. ,vol. 12, pp. 995- 1005 ,(1973) , 10.1128/JVI.12.5.995-1005.1973
Alessandro Trevisan, Giuseppe Realdi, Alfredo Alberti, Giuseppe Ongaro, Elios Pornaro, Riccardo Meliconi, Core antigen-specific immunoglobulin G bound to the liver cell membrane in chronic hepatitis B Gastroenterology. ,vol. 82, pp. 218- 222 ,(1982) , 10.1016/0016-5085(82)90007-5
G Realdi, Alfredo Alberti, Massimo Rugge, Flavia Bortolotti, AM Rigoli, F Tremolada, A Ruol, None, Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection Gastroenterology. ,vol. 79, pp. 195- 199 ,(1980) , 10.1016/0016-5085(80)90130-4
U. Tage-Jensen, H. Permin, F. Hardt, E. Juhl, L. R. Mathiesen, J. O. Nielsen, L. Ranek, , Circulating autoantibodies in patients with acute viral hepatitis. Relation to etiology and clinical course. Scandinavian Journal of Gastroenterology. ,vol. 15, pp. 229- 235 ,(1980) , 10.3109/00365528009181460
Peter Thomas, Carol A. Toth, Norman Zamcheck, The mechanism of biliary excretion of α1‐acid glycoprotein in the rat: Evidence for a molecular weight‐dependent, nonreceptor‐mediated pathway Hepatology. ,vol. 2, pp. 800- 803 ,(1982) , 10.1002/HEP.1840020610