Molecular targeting therapy for pancreatic cancer.
作者： HenryQ. Xiong
DOI: 10.1007/S00280-004-0890-2
关键词: Protein kinase B 、 Tyrosine kinase 、 Farnesyl Transferase Inhibitor 、 Medicine 、 Kinase 、 Pancreatic disease 、 Cancer research 、 Pancreatic cancer 、 Epidermal growth factor receptor 、 EGFR inhibitors 、 Immunology
摘要: Pancreatic carcinogenesis is driven by multiple genetic and epigenetic changes. The epidermal growth factor receptor (EGFR) its downstream signaling pathways, Ras-Raf-MEK-ERK axis, play important roles in pancreatic cancer development. phosphoinositol 3 kinase (PI3 K)/Akt the nuclear κB (NF-κB) pathways control both proliferation resistance to apoptosis of cancer. role cyclooxygenase (COX) lipoxygenase (LOX) development has been made known recently. elucidation these molecular events led several distinct therapeutic advances, including therapies that target EGFR, COX-2 LOX others. Many novel agents have developed are undergoing clinical investigation, such as monoclonal antibodies against tyrosine inhibitors (TKIs), farnesyl transferase (FTIs), Bay43-9006, CI-1040, CCI-779, celecoxib, LY293111. This review highlights recent advances agents.
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