Destruction of bacterial biofilms by polymorphonuclear neutrophils: relative contribution of phagocytosis, DNA release, and degranulation.
作者： Eva Meyle , Petra Stroh , Frank GüNther , Torsten Hoppy-Tichy , Christof Wagner
DOI: 10.1177/039139881003300906
关键词: Lactoferrin 、 Elastase 、 Immunology 、 Bacteria 、 Phagocytosis 、 Granulocyte 、 Biofilm 、 Degranulation 、 Biology 、 Microbiology 、 Context (language use)
摘要: Bacteria organized in biofilms are a common cause of relapsing or persistent infections, and the ultimate implant-associated osteomyelitis. In these patients, staphylococci prevalent. as relatively resistant towards antibiotics biocides, it is also assumed that they may escape host defense mechanisms. this context, we have studied how polymorphonuclear neutrophils (PMN), "first line defense" against bacterial infection, interact with generated vitro. We found PMN recognize activate defense-associated reactions, including phagocytosis, degranulation lactoferrin elastase, DNA release well. Destruction ensues, showing not inherently protected attack by phagocytic cells.
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