Host defense against implant infection: the ambivalent role of phagocytosis.

摘要: Bacteria embedded in biofilms resist both antibiotics and host defense mechanisms. However, are not inherently protected against the attack of phagocytic cells. The weapons that polymorphonuclear neutrophils employ implant infection phagocytosis, degranulation, with release antimicrobial molecules, formation Neutrophil Extracellular Traps (NETs). NETs contain DNA, histones, neutrophil elastase, which enable to fulfill their role limiting microbial spread collateral damage from granular contents. It is yet clear whether DNA released by would support biofilm adding bacterial extracellular (eDNA), an integral part matrix. In spite evidence somewhat effective phagocytosis around infection, biofilm-embedded staphylococci persist, tissue destruction occurs and, case orthopedic osteolysis prevails. mechanism for based on infiltration persistence at site unable effectively perform but able inflict cause proteolytic collagenolytic enzymes. Phagocytosis thus has ambiguous ambivalent role: it carries out antibacterial strategy same time responsible osteolysis.