The Calibrated Automated Thrombogram (CAT): a universal routine test for hyper- and hypocoagulability

摘要: Summary By using a “slow” fluorogenic thrombin substrate and continuous comparison to simultaneously run calibrator, generation can be monitored automatically, on line, in clotting PPP or PRP at throughput of up 100 samples per hour. The resulting “Thrombogram” measures hypocoagulability (haemophilias, oral anticoagulants, heparins (-likes), direct inhibitors) hypercoagulabilities (AT deficiency, prothrombin hyperexpression, prot.C S factor V Leiden, contraceptives). In it is diminished thrombopathies, von Willebrand disease, by antibodies blocking GPIIb-IIIa GPIb, antiplatelet drugs like aspirin clopidogrel. Lupus anticoagulant both retards increases generation.The thrombogram thus appears broad function test the haemostatic- thrombotic mechanism blood.