Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules.
作者： Toshiko Sakihama , Alex Smolyar , Ellis L. Reinherz
DOI: 10.1016/0167-5699(95)80081-6
关键词: MHC restriction 、 Antigen presentation 、 T-cell receptor 、 Biology 、 CD74 、 MHC class I 、 Biophysics 、 MHC class II 、 Molecular biology 、 Major histocompatibility complex 、 Antigen processing
摘要: Recent evidence indicates that CD4 stably binds to major histocompatibility complex (MHC) class II only after assuming an oligomeric state: the membrane-distal D1-D2 module interacts directly with MHC II, whereas membrane-proximal D3-D4 mediates oligomerization. This results in formation of aggregates critical for T-cell activation. The receptor (TCR) regulates specific crosslinking and is itself dependent on lattice trigger physiological responses. Here, Toshiko Sakihama, Alex Smolyar Ellis Reinherz discuss molecular nature CD4-MHC clustering how, despite each component interactions being low affinity, matrix renders recognition extremely sensitive.
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