Topography of cerebellar nuclear projections to the brain stem in the rat.

摘要: The organization of the cerebellum is characterized by a number parallel and parasagittally ordered olivocorticonuclear modules; as such, cerebellar nuclei basically function output system these modules. present study provides comprehensive detailed description connections from to brain stem in rat. Thirteen small injections with anterograde tracer Phaseolus vulgaris leucoagglutinin or biotinylated dextran amine which were centered on various aspects nuclear complex are described illustrated serial plots detailing distribution labeled varicosities throughout stem. In every case at least 1,000 an up 36,000 plotted. All resulted some heavy labeling concentrated within specific regions contralateral inferior olivary and, usually, ventrolateral thalamus. However, apart two areas it shown that projections generally very widespread may be found entire Below, only survey main projection will given. Terminal arborizations originating rostral part medial nucleus mostly caudal half emphasis vestibular complex, whereas its rather connects midbrain areas. Terminals originate dorsolateral protuberance distributed more evenly confined reticular interstitial cell groups, interspersed between both interposed nuclei, provide major ipsilateral mesodiencephalic regions. also targeted over large rostrocaudal range. posterior sends most caudomedial red nucleus, prerubral parvicellular formation, all injection site. Projections laterally placed directed, stem, where superior colliculus zona incerta. anterior specifically targets olive, pontine reticulotegmental prectectum thalamic nucleus. More project formation deep layers spinal trigeminal complex. latter hump. addition, pretectum but do not seem reach lateral terminals. Especially, aspect sends, mesencephalic periaquaductal gray, pretectum, area, several regions, prominent terminate olive gigantocellular formation. ventral, mostly, exclusively, directed mainly pararubral accessory oculomotor pretectal areas, incerta, parafascicular nuclei. We conclude impact widespread; different same show important differences On other hand, result simila