The Relationship between dN/dS and Scaled Selection Coefficients

作者: Stephanie J. Spielman , Claus O. Wilke

DOI: 10.1093/MOLBEV/MSV003

关键词: GeneticsMechanism (biology)BiologyContrast (statistics)Natural selectionData sequencesMathematical relationshipPositive selectionNegative selectionSelection (genetic algorithm)Algorithm

摘要: … We find that dN/dS values can be precisely calculated from scaled selection coefficients, and that dN/dS accurately captures the selective pressures indicated by a given distribution of …

参考文章(80)
Nick Goldman, Ziheng Yang, A codon-based model of nucleotide substitution for protein-coding DNA sequences. Molecular Biology and Evolution. ,vol. 11, pp. 725- 736 ,(1994) , 10.1093/OXFORDJOURNALS.MOLBEV.A040153
David S. Lawrie, Philipp W. Messer, Ruth Hershberg, Dmitri A. Petrov, Strong Purifying Selection at Synonymous Sites in D. melanogaster PLoS Genetics. ,vol. 9, pp. e1003527- ,(2013) , 10.1371/JOURNAL.PGEN.1003527
Ashley Acevedo, Leonid Brodsky, Raul Andino, Mutational and fitness landscapes of an RNA virus revealed through population sequencing Nature. ,vol. 505, pp. 686- 690 ,(2014) , 10.1038/NATURE12861
Y. O. Zhu, M. L. Siegal, D. W. Hall, D. A. Petrov, Precise estimates of mutation rate and spectrum in yeast Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 201323011- ,(2014) , 10.1073/PNAS.1323011111
Sergei Kosakovsky Pond, Spencer V. Muse, Site-to-Site Variation of Synonymous Substitution Rates Molecular Biology and Evolution. ,vol. 22, pp. 2375- 2385 ,(2005) , 10.1093/MOLBEV/MSI232
J. L. Thorne, S. C. Choi, J. Yu, P. G. Higgs, H. Kishino, Population Genetics Without Intraspecific Data Molecular Biology and Evolution. ,vol. 24, pp. 1667- 1677 ,(2007) , 10.1093/MOLBEV/MSM085
G. Sella, A. E. Hirsh, The application of statistical physics to evolutionary biology. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 9541- 9546 ,(2005) , 10.1073/PNAS.0501865102