Proliferation of vascular smooth muscle cells in glioblastoma multiforme.
作者： Hiroaki Takeuchi , Norichika Hashimoto , Ryuhei Kitai , Toshihiko Kubota , Ken-ichiro Kikuta
关键词: Cancer research 、 Vascular endothelial growth factor 、 Vascular smooth muscle 、 Growth factor 、 Neovascularization 、 Biology 、 CD31 、 Microvessel 、 Endothelial stem cell 、 Angiogenesis 、 Immunology
摘要: Object Glioblastomas multiforme (GBM) contain a higher number of α-smooth muscle actin (SMA)–positive vascular smooth cells (VSMCs) than those in the respective normal neuronal tissue. The role VSMCs during angiogenesis is unclear, and it also uncertain whether to what extent angiogenic factors might be involved GBM VSMCs. In GBMs, contribution accompanying endothelial proliferation correlation VSMC with growth factor (VEGF) expression were examined using an immunohistochemical method. Methods material, including surrounding brain tissue, came from 12 cases (6 men 6 women) classic GBM. Microvessel densities (MVDs) CD31-immunoreactive vessels (CD31-MVD) SMA-immunoreactive (SMA-MVD) obtained areas selected white matter, boundary, tumor (concentrated area cells), perinecrosis. Subsequently, SMA-MVD/CD31-MVD (SMA/CD31) rate, representing percenta...
sci-hub.se 参考文章(20)
Balázs Döme, Mary JC Hendrix, Sándor Paku, József Tóvári, József Tímár, None, Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications. American Journal of Pathology. ,vol. 170, pp. 1- 15 ,(2007) , 10.2353/AJPATH.2007.060302
I. Otte-Höller, P. Wesseling, D. J. Ruiter, M. M. Verbeek, R. M. W. De Waal, Induction of alpha-smooth muscle actin expression in cultured human brain pericytes by transforming growth factor-beta 1. American Journal of Pathology. ,vol. 144, pp. 372- 382 ,(1994)
Napoleone Ferrara, Hans Peter Gerber, None, Vascular endothelial growth factor: molecular and biological aspects. Current Topics in Microbiology and Immunology. ,vol. 237, pp. 1- 30 ,(1999) , 10.1007/978-3-642-59953-8_1
Souheil F. Haddad, Steven A. Moore, Robert L. Schelper, James A. Goeken, Vascular smooth muscle hyperplasia underlies the formation of glomeruloid vascular structures of glioblastoma multiforme. Journal of Neuropathology and Experimental Neurology. ,vol. 51, pp. 488- 492 ,(1992) , 10.1097/00005072-199209000-00002
Ondine Cleaver, Douglas A Melton, Endothelial signaling during development. Nature Medicine. ,vol. 9, pp. 661- 668 ,(2003) , 10.1038/NM0603-661
Shunichi Morikawa, Peter Baluk, Toshiyuki Kaidoh, Amy Haskell, Rakesh K. Jain, Donald M. McDonald, Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors American Journal of Pathology. ,vol. 160, pp. 985- 1000 ,(2002) , 10.1016/S0002-9440(10)64920-6
Lawrence P. Reynolds, Anna T. Grazul-Bilska, Dale A. Redmer, Angiogenesis in the corpus luteum. Endocrine. ,vol. 12, pp. 1- 9 ,(2000) , 10.1385/ENDO:12:1:1
Ping Guo, Bo Hu, Weisong Gu, Li Xu, Degui Wang, Hui-Jen Su Huang, Webster K. Cavenee, Shi-Yuan Cheng, Platelet-Derived Growth Factor-B Enhances Glioma Angiogenesis by Stimulating Vascular Endothelial Growth Factor Expression in Tumor Endothelia and by Promoting Pericyte Recruitment American Journal of Pathology. ,vol. 162, pp. 1083- 1093 ,(2003) , 10.1016/S0002-9440(10)63905-3
Amyn M. Rojiani, Katerina Dorovini-Zis, Glomeruloid vascular structures in glioblastoma multiforme: an immunohistochemical and ultrastructural study Journal of Neurosurgery. ,vol. 85, pp. 1078- 1084 ,(1996) , 10.3171/JNS.1996.85.6.1078
Sybill Patan, Beat Haenni, PeterH. Burri, Evidence for intussusceptive capillary growth in the chicken chorio-allantoic membrane (CAM). Anatomy and Embryology. ,vol. 187, pp. 121- 130 ,(1993) , 10.1007/BF00171743